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That's pop-neuro-psych gibberish marketing talk--molecules aren't moods any more than motor oil is velocity. Also, synaptic serotonin is in a different compartment. But I was pondering about the link between SSRIs and weight gain.


"But I was pondering about the link between SSRIs and weight gain."

Indeed, there may be some connection there. But frustratingly, we don't really know what the connection is, or if it has multiple factors--and if so, how those factors relate to one another. To date (to the best of my knowledge), reports of weight gain from people taking SSRIs have been anecdotal. There is a large enough sample size to draw a clear connection; the weight gain isn't imaginary. (It occurs in about 25% of SSRI users, and the risk for weight gain increases over the duration of SSRI usage.) But there haven't been controlled, clinical studies of of the effect. Do SSRIs affect metabolism in some way? Possibly. Do they affect appetite instead, or in addition to, metabolism? Possibly. Do they affect gut microflora? Possibly. Could be any of these things; could be all of these things; could be something we haven't even hypothesized yet. There is a relationship; we don't yet know the directionality of cause and effect, or the factors involved, or their individual significance in the causal web.

These new results are fascinating, and they give further impetus for further study.


But brain chemistry is inextricably linked to human moods. That's why we prescribe people psychoactive drugs. And why people take them recreationally.


Ask anyone who has ever been on Paxil (a common SSRI) if they've had any weight gain. It's nicknamed "Packs-on" for a reason.


Your first sentence contains an amazing turn of phrase. Thank you.




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