Isn't that because the twins are designed to a higher standard, due to regulations such as ETOPS? It's not something inherent in two vs four engine designs?
I remember when the US Navy was rejecting single engine aircraft, and the F135 had be be proven literally bulletproof before they would even look at the F-35.
While true, aircraft fatality statistics generally are not split that way.
The 747 is a safe aircraft, but there have been a lot of fatalities associated with it, due to pilot error, terrorism, improper repair/maintenance, etc.
Not sure if you ever make it over to HKG but there are quite a few cargo 747s that still seem to be making the rounds. CX and others have them on the GA / cargo side, and when on Lantau you often see (and hear!) them on final or takeoff.
I think CX would hate to retire them because from what I understand their load capacity is unparalleled. And you can load horses in them! There'll always be money from that for HAECO to keep them aloft.
It's even better when you're at the bus terminal at HKIA and watching them fly overhead...
Four engines are also less safe than twin engines. I know it sounds counter-intuitive, but Boeing did the math and made the case.