The issues would generally be 1) traffic (a genuine hazard) and 2) bike parking. Many locations have few, if any, bike racks, and often other street furniture (signage, posts, fences) is poorly-suited to securing a bike.

Downtown / midtown areas are often far more amenable than outlying locations, particularly at malls and office parks.

This isn't to say that you cannot bike places, or take risks (collisions, theft), but it's additional friction. As I said, the infrastructure, by American standards, is actually pretty good. I'm just highlighting the limitations / caveats.